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J Clin Endocrinol , 80: 425-431
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Non-cleavable linkers, commonly including maleimide and thiolactam, facilitate the conjugation of payload with antibodies or peptides by forming an amide bond (as in the linker in Kadcyla in Figure 6) or a thioether bond (as in the linker in Blenrep in Figure 6)
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Temperature fluctuations during handling, brief exposure to warmth when drawing doses, and agitation all contribute to peptide degradation over time
As a medicine, it is used to treat burns, scratches, and wounds
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